Hirsutella ThompsoniiCustomer Rating: 0 Write a Review
Code: 07 Form Availability: Liquid The product contains highly effective naturally occurring entomo pathogenic fungus that parasitizes several insect- pests of agricultural importance. Cells become hypotrophied and internal organelles and cell membranes are disrupted. Hirsutellin is a mycotoxin of a invertebrate mycopathogen determined to possess ribosomal inhibiting activity and appears to possess some specificity to invertebrate cells. The mite fungal pathogen Hirsutellathompsonii produces a single polypeptide chain, insecticidal protein name dhirsutellin A (HtA) that is composed of 130 amino acid residues. This protein has been purified from its natural source and produced as a recombinant proteinin Escherichia coli. HtA specifically inactivate sribosomes and produces the alpha-fragment characteristic of ribotoxin activityon rRNA. Behaving as a cyclizing ribonuclease, HtA specifically cleavesoligonucleotides that mimick the sarcin/ricin loop of the ribo some, as well as selected polynucleotides and dinucleosides. HtA interacts with phospholipid membranes as do other ribotoxins. As a consequence of its ribo nuclease activity and its ability to interact with cell membranes, HtA exhibits cytotoxic activity. H. thompsonii can cause spectacular natural epizootics among mite populations (citrus rust, blueberry,coconut,tomato mites, etc.) and is considered to be one of the key natural enemies of various mite pests. Advantage
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